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Patients who continue treatment over a year or more can maintain their weight loss or continue to lose weight

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While routine dietary intake of vitamin B3 is safe during pregnancy and breastfeeding, high-dose supplements and novel precursors like NR should be avoided unless specifically recommended by a healthcare professional

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Figure 1 2 MASLDs pathophysiology and current treatment MASLD is characterized by an abnormal accumulation of lipids in hepatocytes, commonly occurring in the context of obesity, insulin resistance, and T2DM-key features of metabolic syndrome that substantially affect patient quality of life and long-term prognosis ( The complex pathophysiology of MASLD calls for integrated, multi-faceted therapeutic regimens and improved diagnostic tools to enhance clinical outcomes

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The positive predictive value of DSE is likely highest when there is a biphasic response: improvement at low dose dobutamine but worsening function at high dose

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These changes in eating habits help with weight loss and may similarly impact cravings for addictive substances, including alcohol, by dampening the motivation and pleasure derived from alcohol consumption

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