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Patients who continue treatment over a year or more can maintain their weight loss or continue to lose weight

While routine dietary intake of vitamin B3 is safe during pregnancy and breastfeeding, high-dose supplements and novel precursors like NR should be avoided unless specifically recommended by a healthcare professional

Figure 1 2 MASLDs pathophysiology and current treatment MASLD is characterized by an abnormal accumulation of lipids in hepatocytes, commonly occurring in the context of obesity, insulin resistance, and T2DM-key features of metabolic syndrome that substantially affect patient quality of life and long-term prognosis ( The complex pathophysiology of MASLD calls for integrated, multi-faceted therapeutic regimens and improved diagnostic tools to enhance clinical outcomes
The positive predictive value of DSE is likely highest when there is a biphasic response: improvement at low dose dobutamine but worsening function at high dose

These changes in eating habits help with weight loss and may similarly impact cravings for addictive substances, including alcohol, by dampening the motivation and pleasure derived from alcohol consumption
