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Description
In addition, the leptin-receptor-expressing (LepR) neural activity in the dorsomedial hypothalamus (DMH), which sends GABAergic inhibitory inputs to ARC AgRP neurons, is also known to be rapidly increased by sensory detection, the taste of food, or food cues [48,53,54]
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This synergistic interaction enhances overall insulinotropic and glucoregulatory efficacy, positioning tirzepatide as a first-in-class dual incretin receptor agonist with superior metabolic outcomes
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Add creatine, titrate the dose slowly, and get a baseline DEXA scan
