glp-1 alzheimer's Repurposing glucagon-like peptide-1 receptor agonists for the treatment of neurodegenerative disorders GLP-1 improves the neuronal supportive

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As GLP-1 receptor agonists, these peptide drugs mimic the incretin hormone GLP-1, enhancing glucose-dependent insulin secretion, suppressing glucagon release, delaying gastric emptying, and reducing appetite [9]

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Cryo-EM and molecular dynamics simulation analysis of peptide variants of GLP-1 and exendin-4 reveal distinct receptor conformers with unique modes of peptidereceptor engagement.

Secondary outcomes were evaluation of body composition parameters, total adverse events (TAEs) and severe adverse events (SAEs)