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Iatrogenic hyperinsulinemia, not hyperglycemia, drives insulin resistance in type 1 diabetes as revealed by comparison with GCK-MODY (MODY2)

For consumers , it could offer modest short-term savingsthough actual benefits will depend on dosing and duration

What matters is the approach: both start low and titrate up over months

Additionally, GLP-1 receptor agonists slow gastric emptying, which prolongs the feeling of fullness after eating, and they act on appetite centres in the hypothalamus to reduce hunger and food intake

The compulsive or addictive components of primary polydipsia may therefore be targeted by GLP-1 RAs