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Lim SW, Jin L, Jin J, Yang CW

So I think it's important for us to know these complications, to get better at managing the complications, but you know, obesity in this country, and really almost globally, is an epidemic

soft or brittle bones (osteomalacia, osteopenia, osteoporosis)

Weight loss results depend on multiple factors including diet, exercise, adherence to treatment, and individual physiology

The mechanism accounting for this effect is unknown but a leading hypothesis is that an increase of sodium chloride in the macula densa due to SGLT2 inhibition triggers a cascade that reduces GFR through constriction of the afferent glomerular arterioles (tubuloglomerular feedback) (139,195)