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Notably, in line with the previous findings that intestinal FXR was not required for maintaining the normal glucose homeostasis 32 , the glucose metabolism was normal in IFXRKO mice in euthyroid state, suggesting that compensatory mechanisms may exist (Supplementary Fig
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Extended titration, where you stay at a lower dose for longer before increasing, is the evidence-based approach to managing GI side effects and may solve your problem without any experimental modifications
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The findings were surprising
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