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12-14 Exenatide is available in pen form, potentially making dosing and administration more convenient ( TABLE 1 )

Liraglutide (LIRA) and semaglutide (SEMA) gained approval by the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for weight reduction in obese individuals or people who are overweight with BMI 27 kg/m 2 and also experience at least one weight-associated comorbid situation (such as hypertension, dyslipidemia, prediabetes and OSA) combined to lifestyle modifications [71]

By targeting these chemicals in the brain, Contrave helps to promote weight loss

Expert Insights Most people with T2D will eventually need combined therapy, and the GLP1-RAs/SGLT2is combination may prove more effective in some groups of patients

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