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GLP-1 , 2 GLP-1 7 Evaluation of Lixisenatide in Acute Coronary Syndrome (ELIXA) [15], Liraglutide Effect and Action in Diabetes: Evaluation of cardiovascular outcome Results (LEADER) [16], Trial to Evaluate Cardiovascular and Other Long-term Outcomes with Semaglutide in Subjects with Type 2 Diabetes (SUSTAIN-6) [17], EXenatide Study of Cardiovascular Event Lowering (EXSCEL) [18], Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes) [19], Researching cardiovascular Events with a Weekly INcretin in Diabetes (REWIND) [20], Peptide Innovation for Early Diabetes Treatment (PIONEER 6) [21] GLP-1
(2018) Glucose-dependent insulinotropic polypeptide is required for moderate high-fat diet- but not high-carbohydrate diet-induced weight gain
By comparison, the STEP 1 trial for semaglutide reported 14.9% at 68 weeks, and SURMOUNT-1 for tirzepatide reported 20.9% at 72 weeks
