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Moreover, when fat mass shrinks especially rapidly under GLP-1 therapy stored lipophilic (fat-soluble) toxins are released into circulation

Gently swirl to dissolve rather than shaking, which can damage the peptide structure

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Proper storage and handling of tirzepatide is essential: the medication should be stored in a refrigerator at 28C, and patients should follow the specific instructions in the Patient Information Leaflet regarding how long to allow the pen to warm before injection

2008;3(Suppl 2):S2937
