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This action may counteract any appetitelowering activity caused by the high GLP1 levels, leading to an insignificant impact on body weight

Here, we identified that DPP4 in hepatocytes but not TEK receptor tyrosine kinasepositive endothelial cells regulates the local bioactivity of incretin hormones and gluconeogenesis

However, this effect was partially reversed by liraglutide (Fig

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In 2023, the FDA launched an investigation after GLP-1 agonist users started reporting thoughts of suicide as of January 2024, it hadnt found anything to confirm the connection, but it also said it couldnt yet rule it out, meaning its possible the drugs could cause mental health issues for some people, rather than treating or preventing them