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Table 3 summarizes RCTs of the dual and triple GLP1-RA use in obesity

Increasing the number of intestinal endocrine L-cells According to the impairment of L-cells development in T2DM, a promising strategy for treating T2DM is to increase the number of L-cells in the intestine, thereby increasing the production of GLP-1

The mutational constraint spectrum quantified from variation in 141,456 humans

Unlike sustained receptor agonism by GLP-1R agonists (6, 22, 23), the novel dual agonist I-M-150847 induces unique spatiotemporal incretin receptor signaling that promotes cAMP generation at the plasma membrane promoting glucose-stimulated insulin exocytosis

Yu et al., 2012)