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Addiction involves reward circuitry, executive control systems, stress responses, social learning, and metabolic processes, all interacting in ways were still working to understand

Excess body weight increases hydrostatic pressure in the venous and lymphatic systems, elevates inflammatory cytokines, and may directly damage lymphatic vessels through lipotoxicity and chronic low-grade inflammation

Weight often returns when people stop taking these medications without making lasting lifestyle changes

Endocrinology 157: 34053409, 2016

Some patients may see noticeable changes within the first few months, while others may respond more gradually