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Participants must have excess weight, a history of heart attack, stroke, or presence of peripheral arterial disease, and also a history of at least 1 self-reported unsuccessful dietary effort to reduce body weight in order to meet the eligibility criteria

The cardioprotective properties of BBR are ascribed to multiple mechanisms: its antioxidant capabilities, anti-inflammatory effects following ischemia, promotion of coronary vasodilation, anti-apoptotic properties, inhibition of autophagy, and facilitation of angiogenesis after I/R injury (Fig

29 A prospective, nonrandomised pilot study conducted by Campforts et al

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B., Lau J., The Discovery and Development of Liraglutide and Semaglutide