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Snchez-Garrido MA, Serrano-Lpez V, Ruiz-Pino F, et al

Proposed mechanisms include physical compression of vessels and nerves, induction of glomerular hyperfiltration (48), and activation of the RAAS as well as stimulation of inflammation by local release of cytokines (49)

Mild to moderate transient gastrointestinal side effects were the most frequently reported adverse events associated with tirzepatide treatment (nausea 12%18% vs

Xenobiotica (2013) 43(5):43242

Ueda and colleagues found that 77 suicide deaths occurred among GLP-1 receptor agonist users and 71 among SGLT2 inhibitor users during a mean follow-up period of 2.5 years