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The pathophysiology of MASLD is closely linked to insulin resistance, obesity, type 2 diabetes, and metabolic syndrome

JAMA 2022;327:534-45.ArticlePubMedPMC 129

It is taken first thing in the morning on an empty stomach, with a small amount of water (no more than 4 ounces)

To estimate the number of people worldwide with obesity, we also used 2016 population data for adult men and women from each country from the World Bank

retrospective analysis of 886 patients found retained gastric contents in 24.2% of semaglutide patients versus 5.1% of controls (adjusted odds ratio 5.15, 95% confidence interval 1.9212.92), yet actual aspiration occurred in only 1 of 404 patients (0.24%) [31]