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Yet, we suggest that physicians should pay more attention to patients with diabetes who take GLP1-RAs for glucose control

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However, the initial peak in GLP-1s biphasic secretion is likely mediated not by direct nutrient contact but via a more rapid mechanism such as neural signaling, since the majority of intestinal L-cells are located in the distal ileum, and small intestinal transit time can exceed 3 h [17, 18]

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