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These happen for various reasons: water retention from sodium intake, hormonal fluctuations, increased muscle mass from exercise, or simply normal metabolic variation

This helps ensure that potential risks are carefully considered and that the treatment plan reflects your overall health needs, including your hemophilia management

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Zhou K, Bellenguez C, Spencer CC, Bennett AJ, Coleman RL, Tavendale R, et al

Canagliflozin (SGLT2i) contributes to decreased inflammation, extracellular matrix turnover, and fibrosis (300 mg/day decreased plasma levels of TNF receptor 1, IL-6, matrix metalloproteinase 7, and fibronectin 1 after 2 years of follow-up) [93]