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Population pharmacokinetics of cotadutide in subjects with type 2 diabetes

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A new study combines glucagon-like peptide-1 (GLP1) and estrogen in a single molecule, allowing selective targeting of this conjugate to cells that express the GLP1 receptor

This tri-receptor activity is what fundamentally distinguishes Retatrutide from all preceding incretin research compounds, including dual agonists like Tirzepatide (GLP-1R/GIPR) and single agonists like Semaglutide (GLP-1R only), and is the basis for its position at the leading edge of metabolic peptide research