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Beyond appetite control, GLP-1 also helps regulate blood sugar by supporting insulin release when needed and reducing glucagon secretion

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The lack of overlap in their primary mechanisms of action suggests direct pharmacodynamic interactions are unlikely, but indirect effects through shared physiological pathways cannot be entirely excluded

Ex-4 modulates apoptotic pathways in the hippocampus through the regulation of the expression levels of Bcl2, Bax, and caspase-3 [71], and it improves mitochondrial function and integrity in AD mice through the PI3K/Akt signaling pathway [72]