comparison of glp-1 agonists GLP-1-based therapies: current knowledge differences between native Comparative features of glucagon-like peptide

While the specific mechanism causing the effects on the gastrointestinal tract are not fully elucidated, studies suggest GLP-1 and its analogues likely exert effects on the vagus nerve and inhibit cholinergic neurotransmission in the gastrointestinal system to prevent movement of the intestine

Participants taking tirzepatide lost an average of 15.3% of their body weight after a year, while those on semaglutide lost about 8.3%

Wadden TA, Brown GK, Egebjerg C, Frenkel O, Goldman B, Kushner RF, et al

Eleven amino acid glucagon-like peptide-1 receptor agonists with antidiabetic activity

doi: 10.1111/jdi.12275 75 NauckMRizzoMJohnsonABosch-TrabergHMadsenJCariouB