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Combination of exercise and GLP-1 receptor agonist treatment reduces severity of metabolic syndrome, abdominal obesity, and inflammation: a randomized controlled trial
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There are lots of physiological things were still learning about weight gain and weight loss, but the psychological impacts seem just as complex and difficult to manage

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Nothing else is even close. The very same class of medications, GLP-1 agonists, that he promoted comes from government funded science that started in the 1980s with curious scientists testing a variety of venoms on guinea pig pancreases
