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Future GLP-2 trials in IBD should stratify patients by disease phenotype (mucosal UC, inflammatory CD, stricturing CD) and incorporate serial cross-sectional imaging to monitor for stricture progression, given the mechanistic link between GLP-2R signaling through subepithelial myofibroblasts and intestinal fibrogenesis

These medications may affect the way the brain responds to dopamine signals in these areas, decreasing the overactive reward response that drives impulsivity and cravings for substances, she told Healthline

However, she told the Today hosts that, of the three most common effectsnausea, diarrhea, and constipationshe suffered most from constipation

Severe and rare side effects requiring emergency medical attention include: Pancreatitis: Inflammation of the pancreas causing severe abdominal pain