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In recent years, there have been advances in the development of disease-modifying therapies (DMTs) for AD, with the approval by the US Food and Drug Administration (FDA) of the anti-amyloid monoclonal antibodies aducanumab, lecanemab, and donanemab [11, 12]

The newer, dual-action Tirzepatide tends to be substantially more costly due to its advanced formulation and recent market entry

Nonetheless, for GLP-1 and other specialty meds, the push toward ePA has accelerated because every 30% reduction in approval time translates into concrete gains in patient outcomes (timely titration) and provider efficiency ( [45] ) ( [46] )

PlexusDx's Precision Peptide Genetic Test ($99 add-on after your first treatment month) maps 14 metabolic pathways and 150+ genetic insights specific to peptide therapy response

Growing evidence supports the positive impact of GLP-1 RAs in reducing hepatic cytolysis enzymes [56,61,69,70,71,72,73,74,75,76,77,78,79,80,81] (Table 2)