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For example, in a clinical trial for Wegovy, 4% of adults who have type 2 diabetes and a BMI over 27 (considered overweight) developed diabetic retinopathy, a potential complication of diabetes that leads to blood vessel damage in the retina

Not specifically for the switch

[Google Scholar] 155.Bussolo M, Koettl J, Sinnott E

It has been found that APOE 4 leads to BBB breakdown, decreased cerebral blood flow, neuronal loss and behavioral deficits independently of A (Montagne et al., 2021)