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However, the first non-peptide ligand at GLP-1R was in fact an antagonist, T-0632, which competes with 125 I-Ex4(9-39) at hGLP-1R with an IC 50 of 1.2 M and was able to antagonize GLP-1-induced cAMP production in COS-7 cells (Tibaduiza et al ., 2001)

Appeals are unlikely to succeed when the plan has a blanket exclusion of anti-obesity medications, since that is an employer benefit decision, not a clinical one

60 Although modest at the individual level, a 5 mm Hg SBP reduction has been associated with about a 10% lower risk of major cardiovascular events, including 13% reductions in both stroke and heart failure, 8% in ischemic heart disease, and 5% in cardiovascular death, making these effects important at a population level

This is encouraging, but the data is observational rather than from controlled trials

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