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The researchers suggest that changes in gut microbiome composition, particularly involving Akkermansia muciniphila and Parabacteroides distasonis , may explain the effects on GLP-1 and other gut-brain signaling molecules

For instance, 98% of Medicare Advantage plans cover at least one GLP-1 drug for the treatment of diabetes

That said, these effects are not yet well established clinically, and more research is needed to determine whether they are directly caused by the medication or influenced by factors such as weight loss, metabolic changes, or individual physiology

Not ideal for a drug that should be taken continuously, because the pounds pile back on quickly

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