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Exenatide, the first GLP-1RA approved in 2005, demonstrated clinical efficacy but its low homology with human GLP-1 and gastrointestinal side effects restricted widespread use (Muttenthaler et al., 2021)

In a statement, Phoenix wrote that it regularly reviews ads before and after launch, and that it removed one of the examples cited by The Globe before any external inquiry

People willing to commit to longer treatment and able to tolerate possible GI side effects

The result is a sustained reduction in appetite and food intake that most patients describe not as willpower but as the mental noise around food simply quieting down

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