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However, prolonged CR may diminish turnover in this compartment, occasionally yielding modest gains in trabecular indices as seen in female C57BL6J mice undergoing 30% CR during their vulverable period of accelerated bone resorption (i.e., between 8 and 16 weeks)

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GLP-1 RAs, originally developed for glycemic control in type 2 diabetes, have demonstrated mechanistic plausibility and emerging clinical efficacy in modulating key pathophysiological processes implicated in depression, including insulin resistance, neuroinflammation, and reward system dysregulation

Plateaus, muscle loss, or shifts in appetite are normal, and staying flexible with your goals is key to long-term success