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Because both semaglutides effects and alcohol can irritate the gastrointestinal tract, combining them makes these unpleasant symptoms more likely

Proc Natl Acad Sci U S A (1987) 84:34348

Kleiner, D

Moreover, cardiometabolic effects of GLP-1 are attenuated in obesity and T2D, via mechanisms that may involve impaired p38-MAPK signaling

28 In rodent models, genetic knockout of the GLP-1R reduces bone quality and maturity of the collagen matrix
