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Five medical societies have united on guidance and two recent studies shed new light on the topic.

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Weight loss drugs continue to play out in the global market, with forecasts estimated at a value of US$200 billion by 2030.Leading the rise are oral GLP-1 drugs, with new obesity pills projected to push the GLP-1 market into its next chapter in 2026

(A) Taking sleeve gastrectomy (LSG) and Roux-en-Y gastric bypass (RYGB) as the archetypal examples of metabolic bariatric operations, both procedures lead to a net increase of endogenous GLP-1 with different mechanisms: LSG via rapid gastric emptying and RYGB due to the presence of undigested nutrients in the intestinal lumen in segments rich in L-cells, such as the ileum[45,46]