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Although supported by multiple lines of evidence, the observation that native GIP affects food intake only at supraphysiological doses [934,[937], [938], [939]] is tempered by the demonstration that chemogenetically-induced elevation of endogenous GIP to near-physiological (postprandial) levels improves glucose tolerance in lean mice, and also decreases food intake, effects that vanish with peripheral or central administration of GIPR antagonizing antibodies [120]