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Conclusions/interpretation Our findings do not support an increased risk of SIS when taking GLP-1RA in individuals with type 2 diabetes and obesity

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In islet alpha cells, GLP-1(936) led to inhibition of Ca2+ entry via voltage-gated Ca2+ channels sensitive to -agatoxin, with consequential pertussis-toxin-sensitive depletion of the docked pool of secretory granules, effects that were prevented by the glucagon receptor antagonists REMD2.59 and L-168049

MiraLAX is a gentle laxative designed to treat occasional constipation