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This balancing act was attempted by Novo Nordisk, when they developed a triple agonist , compound 16, which in mice was able to reduce body weight by an average of around 30%, fat mass by around 55% and lean mass by around 10% after 27 days [33]

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In addition to its neuroprotective properties, GIP has been shown to influence the regulation of food consumption and body weight through mechanisms operating within the central nervous system (CNS)

Serum il-23 significantly decreased in obese patients with psoriatic arthritis six months after a structured weight loss intervention

[PubMed] [Google Scholar] 15.Nauck M.A., Meier J.J