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Other tiers you will see below: Moderate (one solid trial or a consistent real-world pattern), Emerging (early or contested signals), and Mechanistic Only (animal or lab work with no human data yet)

Conflict of Interest Statement The authors are employees of nference, inc., which conducts research collaborations with various biopharmaceutical companies, including Eli Lilly and Company and Novo Nordisk A/S, whose GLP-1 receptor agonist products (tirzepatide and semaglutide) are included in this study

[3] [6] The MHRA's Yellow Card scheme allows patients and healthcare professionals to report suspected adverse drug reactions

Science 373 (6556), 813818 (2021)

Glucagon-like peptide-1 decreases intracerebral glucose content by activating hexokinase and changing glucose clearance during hyper-glycemia