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Nonnutritive agonists of sweet taste receptors do increase GLP-1 levels and mice null for one such sweet taste receptor, -gustducin, have reduced GLP-1 responses to an oral glucose load (102)

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Its endogenous form has a plasma half-life of only 2-3 minutes due to rapid degradation by dipeptidyl peptidase-4 (DPP-4) and renal clearance

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The most significant example was retatrutide, Eli Lillys experimental obesity and diabetes treatment that has not yet been submitted for FDA approval

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