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Originally developed for diabetes, GLP-1RAs have become a lifeline for millions seeking effective, sustainable weight loss solutions.

396,397,398,399 GLP-1RAs and nerve cells GLP-1 can modulate peripheral nerves through the ERK (extracellular signal-regulated kinase) signaling pathway, reducing the occurrence of neurological dysfunction

Side effects were mainly mild-to moderate gastro-intestinal symptoms (nausea, vomiting, diarrhoea) mostly occurring with higher doses of retatrutide and with faster titration (Table 2)

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