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Furthermore, for approval of Phase 3 clinical studies, sponsors have been recommended to evaluate NASH and fibrosis independently and to consider the following two primary endpoints: (i) improvement of liver fibrosis greater than or equal to stage 1 (NASH CRN fibrosis score) without worsening of NASH and/or (ii) resolution of NASH (defined by the absence of isolated fatty liver disease or simple steatosis) with no worsening of liver fibrosis