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Though the trial was powered to only detect non-inferiority, the observed (non-significant) hazard ratio for semaglutide vs

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At lower price points, the cost-benefit analysis that led to coverage removal may flip back toward coverage, especially as long-term outcomes data showing reduced cardiovascular events and diabetes progression continues to accumulate

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Moreover, the results of cardiovascular outcome trials in persons with T2D given GLP-1RA demonstrating reduced stroke, myocardial infarction, and cardiovascular death 35 along with the emerging evidence demonstrating positive effects of GLP-1RAs 36,37 on kidney outcomes adds further impetus that these drugs have pleiotropic benefits