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At the beginning of the month, Lilly CEO David Ricks told Bloomberg that he expected the shortage to end very soon, adding that actually today or tomorrow we plan to exit that process. On a recent earnings call, Lilly announced that seven sites are expected to help alleviate the supply issues

But both are very effective, and many patients do great on either

In the Phase 3 ATTAIN-1 trial published in the New England Journal of Medicine in 2025, once-daily orforglipron produced mean body weight reductions of 7.5% (6 mg), 8.4% (12 mg), and 11.2% (36 mg) at 72 weeks, compared with 2.1% for placebo

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These early drugs had to be injected daily and were mainly aimed at improving blood sugar control