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Clinical trials have documented gastrointestinal adverse effects as the most common side effects of GLP-1 medicines

Dose-dependent decline in HbA1c and body weight was associated with semaglutide than placebo at weeks 26 and 52 for both the treatment policy as well as trial product estimand [74]

However, GLP-1 drugs slow digestion, which can affect how some oral medications are absorbed into the body