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Whereas large molecules like peptides and proteins generally have difficulties accessing the brain, many small molecules have unlimited access to the entire brain

5 Metabolic liver disease In a 240-week phase 3 clinical trial of 1,200 adults with metabolic dysfunction-associated steatohepatitis (MASH) and fibrosis stages F2-F3 (mean BMI 34.6), semaglutide 2.4 mg weekly improved liver histology (Non-alcoholic Fatty Liver Disease Activity Score, inflammation, and ballooning and steatosis) in the first 800 participants over 72 weeks

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