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Abbreviations AEC: 3-amino-9-ethylcarbazole ANOVA: Analysis of variance ARRIVE: Animal Research: Reporting of In Vivo Experiments BMI: Body mass index CK: Creatine kinase CK-MB: Creatine kinaseMB ECM: Extracellular matrix FITC: Fluorescein isothiocyanate GLP-1: Glucagon-like peptide-1 GLP-1RA / GLP-1RAs: Glucagon-like peptide-1 receptor agonist(s) H&E: Haematoxylin and eosin HDL: High-density lipoprotein HO-1: Heme oxygenase-1 HOMA-: Homeostatic Model Assessment of -cell function HOMA-IR: Homeostatic Model Assessment of insulin resistance HOMA-IS: Homeostatic Model Assessment of insulin sensitivity IF: Immunofluorescence IFN-: Interferon gamma IL-1: Interleukin-1 beta LDH: Lactate dehydrogenase LDL: Low-density lipoprotein LPS: Lipopolysaccharide(s) MMP-2: Matrix metalloproteinase-2 MMP-9: Matrix metalloproteinase-9 ROS: Reactive oxygen species SD: Standard deviation SEM: Standard error of the mean STEP: Semaglutide Treatment Effect in People with Obesity (trial) SELECT: Semaglutide Effects on Cardiovascular Outcomes in People with Overweight or Obesity (trial) TC: Total cholesterol TG: Triglycerides TGF-: Transforming growth factor beta TIMP-1: Tissue inhibitor of metalloproteinases-1 TMAO: Trimethylamine N-oxide TNF-: Tumor necrosis factor alpha TRIS-EDTA: Trisethylenediaminetetraacetic acid ZO-1: Zonula occludens-1 References Gordeladze, J

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All peptides retained significant helical content, although pGLP-1 had more and eGLP-1 had slightly less than hGLP-1

Trial data shows the steepest loss in the first 36 weeks