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The 1 H DOSY NMR spectra were acquired on a Bruker Avance-lll-800 (800 MHz) spectrometer with a standard-bore Bruker ultra stabilized magnet, equipped with a 5 mm QCI Z-gradient cryoprobe containing a cold 13 C preamplifier, a Z-axis field gradient module, four RF channels with waveform generation, H2-decoupling capability, a sample temperature control unit, and a Linux host computer running TopSpin 4.1.1

Contact your provider if you experience severe vomiting, chest pain, difficulty breathing, or signs of allergic reaction

for category B drugs, there is no evidence of risk in humans, although risks have been noted in animal studies

mild nausea during the first few days at a new dose is normal and typically resolves within 37 days