glp-1 and gip for weight loss Why does GLP‐1 agonist combined with and/or GCG agonist have greater effect than GLP‐1 agonist alone in obese adults without type 2 diabetes? - Jiang - 2025 Are GLP-1 pills less effective

In the positive control group, 200 g of Semaglutide in 100 L of PBS was injected subcutaneously into the animals on day 0, 7, 14, and 21

It has been reported that the treatment of diabetic animal models with exendin-4 can improve bone mechanical properties and prevent bone loss by changing the cortical microstructure and bone composition parameters (mineral crystallinity, collagen maturity, acid phosphate content, and carbonphosphorus ratio) (Mansur et al., 2019)

The two are not equivalent interventions

Others have demonstrated that the positive outcomes of obesity surgery (i.e., changes in body weight and improved glucose homeostasis) are sustained in mice in the absence of GLP-1R or Y2-R, or both GLP-1R and Y2-R 66,67

GLP-1 medications work best when combined with lifestyle changes to diet and physical activity levels