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Gastrointestinal adverse effects, infections, retinopathy, malignant neoplasms and 3 cardiovascular adverse events were reported

The combination increases the risk of side effects significantly

31 As such, GLP-1 RAs and dual GLP/GIP-RAs have emerged as essential drugs for the treatment of patients with type 2 diabetes and, more recently, for the management of weight loss in the absence of diabetes

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