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A study published in 2017 added more concern, nothing that GLP-1 receptor agonists (GLP-1RAs) like semaglutide suppress gastric emptying by inhibiting stomach peristalsis while increasing contraction of the pyloric region

Hydration also supports tolerance and overall well-being

Weight Management For weight management, semaglutide typically begins to show its effects within the first week of use

28-Day Optimization During the month that follows, optimize your weight loss plan, if necessary, after each weekly weigh-in

The trial was sponsored by Eli Lilly, which produces orforglipron and also makes the injectable GLP-1 drug tirzepatide under the brand names Mounjaro for type 2 diabetes and Zepbound for chronic weight loss