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Among adults who have had a documented substance overdose, those who started on a GLP-1 had a 39% lower risk of a repeat overdose within three years of their overdose compared to patients who were never prescribed a GLP-1

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**Functional Screening:** * The 10,000 designed GLP-1RAs underwent virtual screening based on stability, efficacy, and diversity criteria, which narrowed down the candidates to 60

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