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Vadher K, Patel H, Mody R et al (2022) Efficacy of tirzepatide 5, 10 and 15 mg versus semaglutide 2 mg in patients with type 2 diabetes: an adjusted indirect treatment comparison

The math is actually simple once someone explains it clearly

GLP-1 receptors are identified on pancreatic -cells, but are also widely distributed throughout the central nervous system, such as the nucleus tractus solitarius (NTS) [11]

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The goal is muscle retention