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Endocr Metab Immune Disord Drug Targets 2021;21:1895-1904 Waibel M, Wentworth JM, So M, Couper JJ, Cameron FJ, MacIsaac RJ, Atlas G, for the BANDIT Study Group

Genetic Predispositions in GLP-1 Receptor Pathways Individual variation in the GLP-1 receptor gene (GLP1R rs6923761) and related metabolic pathways influences how different people respond to GLP-1 agonists

By administering the peptide during a fasted state when insulin is low, you maximize the peptides ability to stimulate fat breakdown without metabolic interference

NPR pointed out that the drugmakers themselves have advertised heavily, with some commercials including the number of pounds patients lost even when that particular medication was meant for type 2 diabetics
