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Semaglutide and other GLP-1 medications may influence cortisol regulation during weight loss, though direct cortisol suppression is not their primary mechanism

These medications, which include Novo Nordisks semaglutide, sold as Ozempic and Wegovy, and Eli Lillys tirzepatide, sold as Zepbound and Mounjaro, are not recommended for use during pregnancy because their safety for the fetus is unknown and animal studies have suggested potential risk

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GLP-1 receptor agonists are reshaping cardiovascular care but prior authorizations, titration management, and patient counseling can make prescribing feel overwhelming